Cyclic-di-GMP (diammonium)

Cyclic-di-GMP (diammonium)

• CAS Number: 609343-82-0
• UNSPSC Description: Cyclic-di-GMP diammonium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP diammonium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP diammonium can be used in cancer research[1][2][3][4].
• Target Antigen: Endogenous Metabolite; STING
• Type: Natural Products
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
• Applications: Metabolism-protein/nucleotide metabolism
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cyclic-di-gmp-diammonium.html
• Purity: 99.07
• Solubility: H2O : 50 mg/mL (ultrasonic)
• Smiles: O[C@@H]([C@H](N1C=NC2=C1N=C(N)NC2=O)O3)[C@H](OP([O-])(OC[C@@H]4[C@H]([C@H]([C@H](N5C=NC6=C5N=C(N)NC6=O)O4)O)O7)=O)[C@H]3COP7([O-])=O.[NH4+].[NH4+]
• Molecular Weight: 724.47
• References & Citations: [1]Karaolis DK, et al. 3',5'-Cyclic diguanylic acid (c-di-GMP) inhibits basal and growth factor-stimulated human colon cancer cell proliferation. Biochem Biophys Res Commun. 2005 Apr 1;329(1):40-5. |[2]Steinberger O, et al. Elevated expression of the CD4 receptor and cell cycle arrest are induced in Jurkat cells by treatment with the novel cyclic dinucleotide 3',5'-cyclic diguanylic acid. FEBS Lett. 1999 Feb 5;444(1):125-9. |[3]Wang Z, et al. STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice. Cancer Immunol Immunother. 2015 Aug;64(8):1057-66. |[4]Jenal U, et al. Cyclic di-GMP: second messenger extraordinaire. Nat Rev Microbiol. 2017 May;15(5):271-284.Clin Transl Med. 2024 Aug;14(8):e1744.|NPJ Biofilms Microbiomes. 2024 Jun 20;10(1):51.|Gut Microbes. 2022 Jan-Dec;14(1):2119055.|Int J Biol Macromol. 2024 Sep 14:135660.|Mbio. 2021 Oct 26;12(5):e0119221.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, sealed storage, away from moisture)
• Clinical Information: No Development Reported