13C20,15N10-Cyclic di-GMP (sodium)

13C20,15N10-Cyclic di-GMP (sodium)

• UNSPSC Description: 13C20,15N10-Cyclic di-GMP (13C20,15N10-c-di-GMP) is 13C and 15N labeled Cyclic-di-GMP (disodium). Cyclic-di-GMP disodium is a STING agonist and a bacterial second messenger that coordinates different aspects of bacterial growth and behavior, including motility, virulence, biofilm formation, and cell cycle progression. Cyclic-di-GMP disodium has anti-cancer cell proliferation activity and also induces elevated CD4 receptor expression and cell cycle arrest. Cyclic-di-GMP disodium can be used in cancer research[1][2][3][4][5].
• Target Antigen: Endogenous Metabolite; Isotope-Labeled Compounds; STING
• Type: Isotope-Labeled Compounds
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease;Others
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/13c20-15n10-cyclic-di-gmp-sodium.html
• Smiles: O=[13C]1[15NH][13C]([15NH2])=[15N][13C]2=[13C]1[15N]=[13CH][15N]2[13C@H](O[13C@@]([13C@@]3([H])OP(O[13CH2][13C@]([13C@@]4([H])OP5(O[Na])=O)(O[13C@@H]([15N]6[13C]([15N]=[13C]([15NH2])[15NH][13C]7=O)=[13C]7[15N]=[13CH]6)[13C@@H]4O)[H])(O[Na])=O)([13CH2]O5)[H])[13C@@H]3O
• Molecular Weight: 764.16
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Karaolis DK, et al. 3',5'-Cyclic diguanylic acid (c-di-GMP) inhibits basal and growth factor-stimulated human colon cancer cell proliferation. Biochem Biophys Res Commun. 2005 Apr 1;329(1):40-5. |[3]Steinberger O, et al. Elevated expression of the CD4 receptor and cell cycle arrest are induced in Jurkat cells by treatment with the novel cyclic dinucleotide 3',5'-cyclic diguanylic acid. FEBS Lett. 1999 Feb 5;444(1):125-9. |[4]Wang Z, et al. STING activator c-di-GMP enhances the anti-tumor effects of peptide vaccines in melanoma-bearing mice. Cancer Immunol Immunother. 2015 Aug;64(8):1057-66. |[5]Jenal U, et al. Cyclic di-GMP: second messenger extraordinaire. Nat Rev Microbiol. 2017 May;15(5):271-284.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported