PRE-084 (hydrochloride) (Standard)

PRE-084 (hydrochloride) (Standard)

• CAS Number: 75136-54-8
• UNSPSC Description: PRE-084 (hydrochloride) (Standard) is the analytical standard of PRE-084 (hydrochloride). This product is intended for research and analytical applications. PRE-084 hydrochloride is a highly selective σ1 receptor (S1R) agonist, with an IC50 of 44 nM. PRE-084 hydrochloride exhibits good neuroprotective effects, can improve motor function and motor neuron survival in mice. PRE-084 hydrochloride also can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway[1][2][3][4].
• Target Antigen: Akt; NO Synthase; Sigma Receptor
• Type: Reference Standards
• Related Pathways: Immunology/Inflammation;Neuronal Signaling;PI3K/Akt/mTOR
• Field of Research: Neurological Disease; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/pre-084-hydrochloride-standard.html
• Smiles: O=C(C1(C2=CC=CC=C2)CCCCC1)OCCN3CCOCC3.[H]Cl
• Molecular Weight: 353.88
• References & Citations: [1]Marrazzo A, et al. Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity. Neuroreport. 2005 Aug 1;16(11):1223-6. |[2]Peviani M, et al. Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiol Dis. 2014 Feb;62:218-32. |[3]Gao QJ, et al. Sigma-1 Receptor Stimulation with PRE-084 Ameliorates Myocardial Ischemia-Reperfusion Injury in Rats. Chin Med J (Engl). 2018 Mar 5;131(5):539-543. |[4]Su TP, et al. Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand. J Pharmacol Exp Ther. 1991 Nov;259(2):543-50.
• Shipping Conditions: Room temperature