PRE-084 Hydrochloride

CAT: 0026-B3049-5Size: 5 mgDry Ice: NoHazardous: No
CAT#:0026-B3049-5Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PRE-084 is a high affinity sigma receptor 1 (σ1) agonist. It shows Ki values of 2.2 and 13,091 nM for σ1 and σ2 receptors, respectively and an IC₅₀ of 44 nM in the sigma receptor assay. It does not show significant activity for PCP and other receptors (IC₅₀ > 10,000 nM). PRE-084 has beneficial effects in a cellular model of Huntington's disease. It (0.3 μM) decreases the deleterious effects of N-terminal mutant huntington proteins in neuronal PC6.3 cells by activating NF-κB pathway and decreasing oxidative stress. Modulators of sigma receptor 1 may be beneficial against SARS-CoV-2 based on interaction of sigma receptors with SARS-CoV-2 protein Nsp6.
Shipping Conditions
RT
Storage Conditions
-20ºC
Shelf Life
36 months

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Alternative Products

CatalogName
MF-0093606-01PRE-084 hydrochloride
HY-18100A-01PRE-084 (hydrochloride)
HY-18100AR-01PRE-084 (hydrochloride) (Standard)
MBS5759392M-084 hydrochloride
MF-0049947-01M 084 hydrochloride
5807/50M 084 hydrochloride 50 mg
5807/10M 084 hydrochloride 10 mg
MBS6061522-01Ritodrine Hydrochloride (N-[2-(p-Hydroxyphenyl)ethyl]-N-[2-(p-hydroxyphenyl)-2-hydroxy-1-methylethyl]amine Hydrochloride, N-(p-Hydroxyphenylethyl)-4-hydroxynorephedrine Hydrochloride, Du-21220, Miolene, Prempar, Pre-Par)
R2032-20Ritodrine Hydrochloride (N-[2- (p-Hydroxyphenyl) ethyl]-N-[2- (p-hydroxyphenyl) -2-hydroxy-1-methylethyl]amine Hydrochloride, N- (p-Hydroxyphenylethyl) -4-hydroxynorephedrine Hydrochloride, Du-21220, Miolene, Prempar, Pre-Par)
C8549-50PRE-084

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