PRE-084

• Description :

  PRE-084 is a highly selective σ1 receptor (S1R) agonist, with an IC50 of 44 nM. PRE-084 exhibits good neuroprotective effects, can improve motor function and motor neuron survival in mice. PRE-084 also can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway[1][2][3][4].

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Akt; NO Synthase; Sigma Receptor

• Type :

  Reference compound

• Related Pathways :

  Immunology/Inflammation; Neuronal Signaling; PI3K/Akt/mTOR

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease; Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/pre-084.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(OCCN1CCOCC1)C2(CCCCC2)C3=CC=CC=C3

• Molecular Formula :

  C19H27NO3

• Molecular Weight :

  317.42

• Precautions :

  P264-P270-P330-P501

• References & Citations :

  [1]Marrazzo A, et al. Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity. Neuroreport. 2005 Aug 1;16 (11) :1223-6. |[2]Peviani M, et al. Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiol Dis. 2014 Feb;62:218-32. |[3]Gao QJ, et al. Sigma-1 Receptor Stimulation with PRE-084 Ameliorates Myocardial Ischemia-Reperfusion Injury in Rats. Chin Med J (Engl) . 2018 Mar 5;131 (5) :539-543. |[4]Su TP, et al. Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand. J Pharmacol Exp Ther. 1991 Nov;259 (2) :543-50.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [138847-85-5]