PRE-084

PRE-084

• CAS Number: 138847-85-5
• UNSPSC Description: PRE-084 is a highly selective σ1 receptor (S1R) agonist, with an IC50 of 44 nM. PRE-084 exhibits good neuroprotective effects, can improve motor function and motor neuron survival in mice. PRE-084 also can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway[1][2][3][4].
• Target Antigen: Akt; NO Synthase; Sigma Receptor
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Neuronal Signaling;PI3K/Akt/mTOR
• Applications: Neuroscience-Neuromodulation
• Field of Research: Neurological Disease; Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/pre-084.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(OCCN1CCOCC1)C2(CCCCC2)C3=CC=CC=C3
• Molecular Weight: 317.42
• References & Citations: [1]Marrazzo A, et al. Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity. Neuroreport. 2005 Aug 1;16(11):1223-6. |[2]Peviani M, et al. Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiol Dis. 2014 Feb;62:218-32. |[3]Gao QJ, et al. Sigma-1 Receptor Stimulation with PRE-084 Ameliorates Myocardial Ischemia-Reperfusion Injury in Rats. Chin Med J (Engl). 2018 Mar 5;131(5):539-543. |[4]Su TP, et al. Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand. J Pharmacol Exp Ther. 1991 Nov;259(2):543-50.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported