PRE-084 (hydrochloride)
CAT:
804-HY-18100A-03
Size:
200 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PRE-084 (hydrochloride)
- CAS Number: 75136-54-8
- UNSPSC Description: PRE-084 hydrochloride is a highly selective σ1 receptor (S1R) agonist, with an IC50 of 44 nM. PRE-084 hydrochloride exhibits good neuroprotective effects, can improve motor function and motor neuron survival in mice. PRE-084 hydrochloride also can ameliorate myocardial ischemia-reperfusion injury in rats by activating the Akt-eNOS pathway[1][2][3][4].
- Target Antigen: Akt; NO Synthase; Sigma Receptor
- Type: Reference compound
- Related Pathways: Immunology/Inflammation;Neuronal Signaling;PI3K/Akt/mTOR
- Applications: Neuroscience-Neuromodulation
- Field of Research: Neurological Disease; Cardiovascular Disease
- Assay Protocol: https://www.medchemexpress.com/PRE-084-hydrochloride.html
- Solubility: DMSO : 17.5 mg/mL (ultrasonic)|H2O : 33.33 mg/mL (ultrasonic;warming;heat to 60°C)
- Smiles: O=C(C1(C2=CC=CC=C2)CCCCC1)OCCN3CCOCC3.[H]Cl
- Molecular Weight: 353.88
- References & Citations: [1]Marrazzo A, et al. Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity. Neuroreport. 2005 Aug 1;16(11):1223-6. |[2]Peviani M, et al. Neuroprotective effects of the Sigma-1 receptor (S1R) agonist PRE-084, in a mouse model of motor neuron disease not linked to SOD1 mutation. Neurobiol Dis. 2014 Feb;62:218-32. |[3]Gao QJ, et al. Sigma-1 Receptor Stimulation with PRE-084 Ameliorates Myocardial Ischemia-Reperfusion Injury in Rats. Chin Med J (Engl). 2018 Mar 5;131(5):539-543. |[4]Su TP, et al. Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand. J Pharmacol Exp Ther. 1991 Nov;259(2):543-50.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported