IMR-1A
CAT:
804-HY-100431A-04
Size:
100 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
IMR-1A
- CAS Number: 331862-41-0
- UNSPSC Description: IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A[1].
- Target Antigen: Drug Metabolite; Notch
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease;Neuronal Signaling;Stem Cell/Wnt
- Applications: Cancer-programmed cell death
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/IMR-1A.html
- Purity: 98.01
- Solubility: DMSO : 2 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL
- Smiles: O=C(O)COC1=CC=C(/C=C(SC(N2)=S)\C2=O)C=C1OC
- Molecular Weight: 325.36
- References & Citations: [1]Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.
- Shipping Conditions: Room Temperature
- Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
- Clinical Information: No Development Reported