IMR-1

• UNSPSC Description:

  IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth[1].

• Target Antigen:

  Notch

• Type:

  Reference compound

• Related Pathways:

  Neuronal Signaling;Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/IMR-1.html

• Purity:

  98.95

• Solubility:

  DMSO : ≥ 100 mg/mL

• Smiles:

  O=C(OCC)COC1=CC=C(/C=C(SC(N2)=S)\C2=O)C=C1OC

• Molecular Weight:

  353.41

• References & Citations:

  [1]Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  310456-65-6