IMR-1A

• UNSPSC Description:

  IMR-1A, a acid metabolite of IMR-1, is a Notch inhibitor with an IC50 of 0.5 μM. IMR-1A has a 50-fold increase in potency with respect to IMR-1. IMR-1 can metabolize in vivo to IMR-1A[1].

• Target Antigen:

  Drug Metabolite; Notch

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease;Neuronal Signaling;Stem Cell/Wnt

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/IMR-1A.html

• Purity:

  98.01

• Solubility:

  DMSO : 2 mg/mL (ultrasonic)|H2O : < 0.1 mg/mL

• Smiles:

  O=C(O)COC1=CC=C(/C=C(SC(N2)=S)\C2=O)C=C1OC

• Molecular Weight:

  325.36

• References & Citations:

  [1]Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  331862-41-0