IMR-1

IMR-1

• CAS Number: 310456-65-6
• UNSPSC Description: IMR-1 is a novel class of Notch inhibitor targeting the transcriptional activation with an IC50 of 26 μM. IMR-1 prevents the recruitment of Mastermind-like 1 (Maml1) to the Notch Ternary Complex (NTC) on chromatin, inhibits Notch target gene transcription and dramatically inhibits tumor growth[1].
• Target Antigen: Notch
• Type: Reference compound
• Related Pathways: Neuronal Signaling;Stem Cell/Wnt
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/IMR-1.html
• Purity: 98.95
• Solubility: DMSO : ≥ 100 mg/mL
• Smiles: O=C(OCC)COC1=CC=C(/C=C(SC(N2)=S)\C2=O)C=C1OC
• Molecular Weight: 353.41
• References & Citations: [1]Astudillo L et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported