PKI-179

• Target:

  MTOR|||Others|||PI3K

• Related Pathways:

  PI3K/Akt/mTOR signaling|||Others

• Bioactivity:

  PKI-179 is a potent, orally active compound that functions as a dual PI3K/mTOR inhibitor. It demonstrates IC50 values of 8 nM for PI3K-?, 24 nM for PI3K-?, 74 nM for PI3K-?, 77 nM for PI3K-?, and 0.42 nM for mTOR. Additionally, it is effective against E545K and H1047R mutations, with IC50s of 14 nM and 11 nM, respectively. In vivo studies have shown that PKI-179 possesses anti-tumor capabilities[1][2].

• Smiles:

  O=C (Nc1ccncc1) Nc1ccc (cc1) -c1nc (nc (n1) N1CCOCC1) N1C2CCC1COC2

• Molecular Formula:

  C25H28N8O3

• Molecular Weight:

  488.54

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1197160-28-3