PKI-179

CAT: 0931-T36084-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-T36084-01Size:25 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
CAS Number
1197160-28-3
Target
MTOR|||Others|||PI3K
Related Pathways
PI3K/Akt/mTOR signaling|||Others
Bioactivity
PKI-179 is a potent, orally active compound that functions as a dual PI3K/mTOR inhibitor. It demonstrates IC50 values of 8 nM for PI3K-?, 24 nM for PI3K-?, 74 nM for PI3K-?, 77 nM for PI3K-?, and 0.42 nM for mTOR. Additionally, it is effective against E545K and H1047R mutations, with IC50s of 14 nM and 11 nM, respectively. In vivo studies have shown that PKI-179 possesses anti-tumor capabilities[1][2].
Smiles
O=C(Nc1ccncc1)Nc1ccc(cc1)-c1nc(nc(n1)N1CCOCC1)N1C2CCC1COC2
Molecular Formula
C25H28N8O3
Molecular Weight
488.54
Shipping Conditions
Cool pack
Storage Temperature
-20°C

Related Products

CatalogName
T3656-01PKI-402
T16549-01PKI-166
T84301-01PT-179
T9774-01BAY-179
T69095-01FAUC-179
T70007-01CT-179
T70100-01SG3-179
T24204Jmv 179
TP1957PKI (5-24)
T36643PKI-166 hydrochloride

Alternative Products

CatalogName
OR1103275-01PKI-179
HY-11080A-01PKI-179 (hydrochloride)
MBS5797294PKI-179 hydrochloride
471200PKI-179 HCl
M40347-01PKI-tide
M33468-01PKI-166
MBS385961-01PKI-402
329789-01PKI beta
E1KS2628PKI-587
462734-01PKI 402

Popular Products