PKI-179

• Target :

  MTOR|||Others|||PI3K

• Related Pathways :

  PI3K/Akt/mTOR signaling|||Others

• Bioactivity :

  PKI-179 is a potent, orally active compound that functions as a dual PI3K/mTOR inhibitor. It demonstrates IC50 values of 8 nM for PI3K-?, 24 nM for PI3K-?, 74 nM for PI3K-?, 77 nM for PI3K-?, and 0.42 nM for mTOR. Additionally, it is effective against E545K and H1047R mutations, with IC50s of 14 nM and 11 nM, respectively. In vivo studies have shown that PKI-179 possesses anti-tumor capabilities[1][2].

• Smiles :

  O=C(Nc1ccncc1)Nc1ccc(cc1)-c1nc(nc(n1)N1CCOCC1)N1C2CCC1COC2

• Molecular Formula :

  C25H28N8O3

• Molecular Weight :

  488.54

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  1197160-28-3