SARS-CoV-2 3CLpro-IN-26

SARS-CoV-2 3CLpro-IN-26

• UNSPSC Description: SARS-CoV-2 3CLpro-IN-26 (Compound (S,R)-4y) is an allosteric inhibitor for SARS-CoV-2 3CLpro with an IC50 of 0.43 μM. SARS-CoV-2 3CLpro-IN-26 exhibits good cell permeability and is able to effectively cross the cell membrane, after co-incubation with Vero-E6 cells[1].
• Target Antigen: SARS-CoV; Virus Protease
• Type: Reference compound
• Related Pathways: Anti-infection
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/sars-cov-2-3clpro-in-26.html
• Smiles: ClC1=CC(Cl)=CC(N[C@H](C2=CC=CC=C2)[C@](C(OC)=O)(C3=CN=C(C=C3)Cl)NC(C#C)=O)=C1
• Molecular Weight: 502.78
• References & Citations: [1]Xue J, et al., Novel Alkynylamide-Based Nonpeptidic Allosteric Inhibitors for SARS-CoV-2 3-Chymotrypsin-like Protease. ACS Pharmacol Transl Sci. 2024 Oct 2;7(10):3170-3191.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported