SARS-CoV-2 3CLpro-IN-26

• UNSPSC Description:

  SARS-CoV-2 3CLpro-IN-26 (Compound (S,R)-4y) is an allosteric inhibitor for SARS-CoV-2 3CLpro with an IC50 of 0.43 μM. SARS-CoV-2 3CLpro-IN-26 exhibits good cell permeability and is able to effectively cross the cell membrane, after co-incubation with Vero-E6 cells[1].

• Target Antigen:

  SARS-CoV; Virus Protease

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/sars-cov-2-3clpro-in-26.html

• Smiles:

  ClC1=CC(Cl)=CC(N[C@H](C2=CC=CC=C2)[C@](C(OC)=O)(C3=CN=C(C=C3)Cl)NC(C#C)=O)=C1

• Molecular Weight:

  502.78

• References & Citations:

  [1]Xue J, et al., Novel Alkynylamide-Based Nonpeptidic Allosteric Inhibitors for SARS-CoV-2 3-Chymotrypsin-like Protease. ACS Pharmacol Transl Sci. 2024 Oct 2;7(10):3170-3191.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported