FGFR2-IN-2

• Description :

  FGFR2-IN-2 (Compound 38) is a selective FGFR2 inhibitor with IC50s of 389, 29, and 758 nM for FGFR1, FGFR2, and FGFR3, respectively[1].

• CAS Number :

  [2677709-81-6]

• UNSPSC :

  12352005

• Target :

  FGFR

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/fgfr2-in-2.html

• Concentration :

  10mM

• Purity :

  98.25

• Solubility :

  DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles :

  OC1=CC=C(C2=CC3=C(C(C4=CC=C(N5CCNCC5)C=C4)=NN3)C=C2)C=C1

• Molecular Formula :

  C23H22N4O

• Molecular Weight :

  370.45

• References & Citations :

  [1]Lewis D Turner, et al. From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor. J Med Chem. 2022 Jan 27;65 (2) :1481-1504.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported