FGFR2-IN-2

• Description:

  FGFR2-IN-2 (Compound 38) is a selective FGFR2 inhibitor with IC50s of 389, 29, and 758 nM for FGFR1, FGFR2, and FGFR3, respectively[1].

• UNSPSC:

  12352005

• Target:

  FGFR

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/fgfr2-in-2.html

• Concentration:

  10mM

• Purity:

  98.25

• Solubility:

  DMSO : 62.5 mg/mL (ultrasonic; warming; heat to 60°C)

• Smiles:

  OC1=CC=C(C2=CC3=C(C(C4=CC=C(N5CCNCC5)C=C4)=NN3)C=C2)C=C1

• Molecular Formula:

  C23H22N4O

• Molecular Weight:

  370.45

• References & Citations:

  [1]Lewis D Turner, et al. From Fragment to Lead: De Novo Design and Development toward a Selective FGFR2 Inhibitor. J Med Chem. 2022 Jan 27;65 (2) :1481-1504.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2677709-81-6]