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FGFR2/3-IN-2

CAT: 0804-HY-170919Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170919Size:1 Each
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Description
FGFR2/3-IN-2 (compound 10) is an orally active FGFR2 and FGFR3 inhibitor. FGFR2/3-IN-2 inhibits FGFR2 and FGFR3 with IC50s of 3.7 nM and 31.2 nM (preincubation time 1 h), respectively. FGFR2/3-IN-2 spares FGFR1/4 and other kinases without causing diarrhea and serum phosphate elevation in vivo. FGFR2/3-IN-2 induces tumor stasis or regression in the SNU-16 gastric cancer model[1].
CAS Number
3025799-28-1
UNSPSC
12352005
Target
FGFR
Related Pathways
Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Smiles
CC1=NC(OC2=CC=C(C=C2)C3=C(N4C(C=NC(C)=C4)=C3C(N)=O)C5=CC=C(C=C5)NC(C(F)=C)=O)=NC=C1
Molecular Formula
C29H23FN6O3
Molecular Weight
522.53
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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