Anticancer agent 201

• UNSPSC Description:

  Anticancer agent 201 (Compound 2f) has IC50 values in the low micromolar range for multiple tumor cell lines. Anticancer agent 201 is highly cytotoxic to CCRF-CEM cells in vitro, inducing apotosis by activating caspase-3 in the intrinsic mitochondrial pathway and lysis of PARP, as well as reducing the expression of Bcl-2 and Bcl-XL proteins. Anticancer agent 201 can be used in cancer research[1].

• Target Antigen:

  Apoptosis; Bcl-2 Family; Caspase; PARP

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Cell Cycle/DNA Damage;Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/anticancer-agent-201.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1C=C(C2C[C@]3([C@@](C(C)(C2O1)C)([H])CC[C@@]4([C@]3([H])CC[C@]5([H])[C@@]6([H])[C@@H](CC[C@@]6(CC[C@]54C)C(O)=O)C(C)C)C)C)C(F)(F)F

• Molecular Weight:

  578.75

• References & Citations:

  [1]Kazakova A, et al. Novel triterpenoid pyrones, phthalimides and phthalates are selectively cytotoxic in CCRF-CEM cancer cells - Synthesis, potency, and mitochondrial mechanism of action. Eur J Med Chem. 2024;269:116336.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  9007-83-4