A 419259
CAT:
804-HY-15764-04
Size:
5 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
A 419259
- CAS Number: 364042-47-7
- UNSPSC Description: A 419259 is a broad-spectrum pyrrolo-pyrimidine inhibitor, has high selectivity towards the Src family. A 419259 shows inhibitory effect for Src, Lck and Lyn with IC50 of 9 nM, [1][2].
- Target Antigen: Apoptosis; Src
- Type: Reference compound
- Related Pathways: Apoptosis;Protein Tyrosine Kinase/RTK
- Applications: Neuroscience-Neuromodulation
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/a-419259.html
- Solubility: DMSO : 12.5 mg/mL (ultrasonic)
- Smiles: NC1=C2C(N([C@H]3CC[C@H](N4CCN(C)CC4)CC3)C=C2C5=CC=C(OC6=CC=CC=C6)C=C5)=NC=N1
- Molecular Weight: 482.63
- References & Citations: [1]Wilson MB, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21(53):8075-88.|[2]Zhang X, et al. Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells. Stem Cell Res. 2014 Nov;13(3 Pt A):379-89.Blood. 2016 Jun 23;127(25):3237-52.|J Med Chem. 2024 Nov 28;67(22):20571-20579.|Patent. US20170333436A1.|Blood. 2016 Jun 23;127(25):3237-52.
- Shipping Conditions: Room Temperature
- Clinical Information: No Development Reported