A 419259

• UNSPSC Description:

  A 419259 is a broad-spectrum pyrrolo-pyrimidine inhibitor, has high selectivity towards the Src family. A 419259 shows inhibitory effect for Src, Lck and Lyn with IC50 of 9 nM, [1][2].

• Target Antigen:

  Apoptosis; Src

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Protein Tyrosine Kinase/RTK

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/a-419259.html

• Solubility:

  DMSO : 12.5 mg/mL (ultrasonic)

• Smiles:

  NC1=C2C(N([C@H]3CC[C@H](N4CCN(C)CC4)CC3)C=C2C5=CC=C(OC6=CC=CC=C6)C=C5)=NC=N1

• Molecular Weight:

  482.63

• References & Citations:

  [1]Wilson MB, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21(53):8075-88.|[2]Zhang X, et al. Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells. Stem Cell Res. 2014 Nov;13(3 Pt A):379-89.Blood. 2016 Jun 23;127(25):3237-52.|J Med Chem. 2024 Nov 28;67(22):20571-20579.|Patent. US20170333436A1.|Blood. 2016 Jun 23;127(25):3237-52.

• Shipping Conditions:

  Room Temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  364042-47-7