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A 419259 (GMP)

CAT: 0804-HY-15764G-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15764G-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A 419259 GMP is the GMP grade A 419259 , inducing cell apoptosis. GMP-grade small molecules can be used as auxiliary reagents in cell therapy. A 419259 (RK-20449) is a broad-spectrum pyrrole-pyrimidine inhibitor targeting Src, Lck, and Lyn with IC50s of 9 nM,[2].
CAS Number
364042-47-7
Product Name Alternative
RK-20449 (GMP)
UNSPSC
12352005
Target
Apoptosis; Src
Type
GMP Small Molecules
Related Pathways
Apoptosis; Protein Tyrosine Kinase/RTK
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/a-419259-gmp.html
Purity
99.80
Solubility
DMSO : 100 mg/mL (ultrasonic; warming)
Smiles
NC1=C2C(N([C@H]3CC[C@H](N4CCN(C)CC4)CC3)C=C2C5=CC=C(OC6=CC=CC=C6)C=C5)=NC=N1
Molecular Formula
C29H34N6O
Molecular Weight
482.63
References & Citations
[1]Wilson MB, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21 (53) :8075-88.|[2]Zhang X, et al. Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells. Stem Cell Res. 2014 Nov;13 (3 Pt A) :379-89.
Shipping Conditions
Blue Ice
Storage Conditions
4°C, sealed storage, away from moisture and light
Scientific Category
GMP Small Molecules
Clinical Information
No Development Reported

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