A 419259 (trihydrochloride)

A 419259 (trihydrochloride)

• CAS Number: 1435934-25-0
• UNSPSC Description: A 419259 trihydrochloride is a Src family kinases inhibitor with IC50s of 9 nM, 3 nM and 3 nM for Src, Lck and Lyn, respectively[1][2].
• Target Antigen: Apoptosis; Src
• Type: Reference compound
• Related Pathways: Apoptosis;Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/A-419259-trihydrochloride.html
• Solubility: DMSO : 1 mg/mL (ultrasonic)|H2O : 50 mg/mL (ultrasonic)
• Smiles: NC1=C2C(N([C@H]3CC[C@H](N4CCN(C)CC4)CC3)C=C2C5=CC=C(OC6=CC=CC=C6)C=C5)=NC=N1.[H]Cl.[H]Cl.[H]Cl
• Molecular Weight: 592.00
• References & Citations: [1]Wilson MB, et al. Selective pyrrolo-pyrimidine inhibitors reveal a necessary role for Src family kinases in Bcr-Abl signal transduction and oncogenesis. Oncogene. 2002 Nov 21;21(53):8075-88.|[2]Zhang X, et al. Src-family tyrosine kinase activities are essential for differentiation of human embryonic stem cells. Stem Cell Res. 2014 Nov;13(3 Pt A):379-89.Blood. 2016 Jun 23;127(25):3237-52.|Blood. 2016 Jun 23;127(25):3237-52.|J Med Chem. 2024 Nov 28;67(22):20571-20579.|Patent. US20170333436A1.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported