PDE5-IN-12

PDE5-IN-12

• UNSPSC Description: PDE5-IN-12 (compound 4h) is a potent phosphodiesterase-5 (PDE-5) inhibitor with an IC50 of 22 nM. PDE5-IN-12 shows anti-proliferative effects against the aortic cell line[1].
• Target Antigen: Phosphodiesterase (PDE)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: Neuroscience-Neuromodulation
• Field of Research: Cardiovascular Disease
• Assay Protocol: https://www.medchemexpress.com/pde5-in-12.html
• Solubility: 10 mM in DMSO
• Smiles: FC1=CC=CC(Cl)=C1/C=N/NC(CN(C(C=C2)=O)N(C3=CC=CC=C3)C2=O)=O
• Molecular Weight: 400.79
• References & Citations: [1]Zeinab S Abd-Rabo, et al. Design, synthesis, and biological evaluation of some new 2-phenyl-3,6-pyridazinedione derivatives as PDE-5 inhibitors. Bioorg Chem. 2024 Feb 16:145:107213.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported