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PDE5-IN-12

CAT: 0804-HY-161290Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-161290Size:1 Each
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Description
PDE5-IN-12 (compound 4h) is a potent phosphodiesterase-5 (PDE-5) inhibitor with an IC50 of 22 nM. PDE5-IN-12 shows anti-proliferative effects against the aortic cell line[1].
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pde5-in-12.html
Solubility
10 mM in DMSO
Smiles
FC1=CC=CC(Cl)=C1/C=N/NC(CN(C(C=C2)=O)N(C3=CC=CC=C3)C2=O)=O
Molecular Formula
C19H14ClFN4O3
Molecular Weight
400.79
References & Citations
[1]Zeinab S Abd-Rabo, et al. Design, synthesis, and biological evaluation of some new 2-phenyl-3,6-pyridazinedione derivatives as PDE-5 inhibitors. Bioorg Chem. 2024 Feb 16:145:107213.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE5

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