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PDE5-IN-10

CAT: 0804-HY-155687Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-155687Size:1 Each
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Description
PDE5-IN-10 (compound 4b) is a potent PDE5 inhibitor with an IC50 of 20 nM. PDE5-IN-10 improves in vitro microsomal stability (t1/2 = 44.6 min) as well as excellent efficacy in restoring long-term potentiation. PDE5-IN-10 can be used for Alzheimer’s disease (AD) research[1].
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pde5-in-10.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC(C2CC2)=C3N=CC(CO)=C(NCC4=CC=C(OC)N=C4)C3=C1
Molecular Formula
C21H20N4O2
Molecular Weight
360.41
References & Citations
[1]Elisa Zuccarello, et al. Optimizing metabolic stability of phosphodiesterase 5 inhibitors: Discovery of a potent N- (pyridin-3-ylmethyl) quinoline derivative targeting synaptic plasticity. Bioorg Med Chem Lett. 2023 Aug 15;92:129409.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE5

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