PROTAC BRD4-binding moiety 1

CAT: 0804-HY-107442-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-107442-01Size:5 mg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
PROTAC BRD4-binding moiety 1 is a ligand for BRD4. PROTAC BRD4-binding moiety 1 binds to cereblon ligand via a linker to form PROTAC to degrade BRD4 (HY-133136) [1]. PROTAC BRD4-binding moiety 1 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
CAS Number
[2101200-10-4]
UNSPSC
12352005
Target
Epigenetic Reader Domain; Ligands for Target Protein for PROTAC
Type
Reference compound
Related Pathways
Epigenetics; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/protac-brd4-binding-moiety-1.html
Purity
99.10
Solubility
DMSO : 120 mg/mL (ultrasonic)
Smiles
O=C1N(C)C2=C(C=C(C3=C(C)ON=C3C)C=C2)C(C4=CC=CC=C4)N1CC#C
Molecular Formula
C23H21N3O2
Molecular Weight
371.43
References & Citations
[1]Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28 (1) :115228.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
BRD4

Related Products

CatalogName
HY-107445PROTAC BRD9-binding moiety 1
HY-107445A-01PROTAC BRD9-binding moiety 1 (hydrochloride)
HY-143270PROTAC BRD9-binding moiety 5
HY-107451-01PROTAC BET-binding moiety 1
HY-107444-01PROTAC Her3-binding moiety 1
HY-43723-01PROTAC BET-binding moiety 2
HY-107450PROTAC Her3-binding moiety 2
HY-130612PROTAC BRD2/BRD4 degrader-1
HY-129939-01PROTAC BRD4 ligand-1
HY-133131-01PROTAC BRD4 Degrader-1

Alternative Products

CatalogName
MBS5771458PROTAC BRD4-binding moiety 1
MBS3845097-01PROTAC BET-binding moiety 2
MBS5753729-01PROTAC BET-binding moiety 1
OR1032169PROTAC CDK9-binding moiety 1
MBS3844587-01PROTAC BRD9-binding moiety 1
MF-0154634-01PROTAC BRD9-binding moiety 5
MBS5768141PROTAC Her3-binding moiety 1
MF-0119382-01PROTAC Her3-binding moiety 2
A20112-10PROTAC BET-binding moiety 1 10mg
A20137-1PROTAC BRD9-binding moiety 1 1mg

Popular Products