ML-T7

• Target :

  Immunology/Inflammation related

• Related Pathways :

  Immunology/Inflammation

• Bioactivity :

  ML-T7, a powerful inhibitor of Tim-3, effectively disrupts its interactions with PtdSer and CEACAM1. This compound enhances the antitumor activity of adoptive transfer therapy involving cytotoxic T lymphocytes (CTLs) and CAR T cells, while also boosting T cell effector functions. Additionally, ML-T7 augments the killing activity of NK cells against tumor cells and improves the antigen-presenting capacity of dendritic cells (DCs) . Demonstrating antitumor efficacy in preclinical models, ML-T7 shows potential either as a standalone treatment or in combination with Nivolumab for tumor immunotherapy research [1].

• Smiles :

  O=C1C2(C3C(C(O2)C4=CC=C(C)C=C4)C(=O)N(C3=O)C5=C(Cl)C=C(Cl)C=C5)C(=O)C=6C1=CC=CC6

• Molecular Formula :

  C27H17Cl2NO5

• Molecular Weight :

  506.33

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  459789-75-4