NOTCH3 Rabbit Polyclonal Antibody

• Description:

  Neurogenic locus notch homolog protein 3 (Notch 3) is a protein that in humans is encoded by the NOTCH3 gene. This gene encodes the third discovered human homologue of the Drosophila melanogaster type I membrane protein notch. In Drosophila, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). Mutations in NOTCH3 have also been identified in families with Alzheimer's disease. Adult Notch3 knock-out mice show incomplete neuronal maturation in the spinal cord dorsal horn, resulting in permanently increased nociceptive sensitivity. Mutations in NOTCH3 are associated to lateral meningocele syndrome.

• Product Name Alternative:

  CADASIL antibody CASIL antibody NOTC3_HUMAN antibody Notch 3 antibody Notch 3 intracellular domain antibody Notch homolog 3 antibody Notch3 antibody

• Abbreviation:

  NOTCH3

• Swiss Prot:

  Q9UM47 Human

• Cellular Locus:

  Cell membrane; Nucleus.

• Host:

  Rabbit

• Species Reactivity:

  Human

• Immunogen:

  Recombinant protein within human NOTCH3 aa 2,022-2,321 / 2,321.

• Isotype:

  IgG

• Conjugation:

  Non-conjugated

• Type:

  Rabbit polyclonal Antibody

• Applications:

  WB, FC

• Positive Control:

  Hela cell lysate, MCF-7 cell lysate, PANC-1 cell lysate, HUVEC cell lysate, Hela.

• Concentration:

  2 mg/mL

• Dilution:

  WB: 1:1,000 ;FC: 1ug/mL

• Purity:

  Immunogen affinity purified.

• Form:

  Liquid

• Buffer:

  PBS (pH7.4), 0.1% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.

• Molecular Weight:

  Predicted band size: 244 kDa

• Storage Conditions:

  Store at +4°C after thawing. Aliquot store at -20°C. Avoid repeated freeze/thaw cycles.

• Recombinant Antibody:

  No

• CAS Number:

  9007-83-4