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Iberiotoxin (TFA)

CAT: 0804-HY-P0190A-01Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0804-HY-P0190A-01Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Iberiotoxin (TFA) is a selective high conductance high conductance Ca2+-activated K+ channel inhibitor with a Kd of ~1 nM. Iberiotoxin (TFA) does not block other types of voltage-dependent ion channels[1][2][3].
UNSPSC
12352209
Target
Potassium Channel
Type
Peptides
Related Pathways
Membrane Transporter/Ion Channel
Applications
Neuroscience-Neuromodulation
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/iberiotoxin-tfa.html
Purity
99.05
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H]([C@H](O)C)C(N[C@@H](CC(O)=O)C(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CSSC[C@H](NC2=O)C(N[C@@H](CCSC)C(NCC(N[C@@H](CCCCN)C(N[C@H]3CCCCN)=O)=O)=O)=O)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CO)C(N[C@@H](CCCCN)C(N[C@@H](CCC(O)=O)C(N[C@@H](CSSC[C@H](NC3=O)C(N[C@H]4CCCNC(N)=N)=O)C(N[C@@H](CC5=CNC6=CC=CC=C56)C(N[C@@H](CO)C(N[C@@H](C(C)C)C(N[C@@H](CSSC[C@H](NC4=O)C(N[C@@H](CC7=CC=C(C=C7)O)C(N[C@@H](CCC(N)=O)C(O)=O)=O)=O)C(N[C@@H](CCCCN)C(N[C@@H](CC(O)=O)C(N[C@@H](CC(C)C)C(N[C@@H](CC8=CC=CC=C8)C(NCC(N[C@@H](C(C)C)C(N[C@@H](CC(O)=O)C(N[C@@H](CCCNC(N)=N)C(NCC(N[C@H]2CCCCN)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CC9)NC9=O.OC(C(F)(F)F)=O.[x]
Molecular Formula
C179H274N50O55S7.xC2HF3O2
Molecular Weight
4230.85 (free base)
References & Citations
[1]Galvez A, et al. Purification and characterization of a unique, potent, peptidyl probe for the high conductance calcium-activated potassium channel from venom of the scorpion Buthus tamulus. J Biol Chem. 1990;265 (19) :11083-11090.|[2]Echeverry S, et al. Activation of BK Channel Contributes to PL-Induced Mesenchymal Stem Cell Migration. Front Physiol. 2020;11:210.|[3]Wang RJ, et al. Downregulation of large conductance calcium-activated potassium channels in paraventricular nucleus contributes to sympathoexcitation in rats with chronic heart failure. Zhonghua Xin Xue Guan Bing Za Zhi. 2018;46 (3) :178-186.
Shipping Conditions
Blue Ice
Storage Conditions
-80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture and light)
Scientific Category
Peptides
Clinical Information
No Development Reported

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