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LY367385 (hydrochloride)

CAT: 0804-HY-107515A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-107515A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
LY367385 hydrochloride is a highly selective and potent mGluR1a antagonist. LY367385 hydrochloride has an IC50 of 8.8 μM for inhibiting of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with >100 μM for mGlu5a. LY367385 hydrochloride has neuroprotective, anticonvulsant and antiepileptic effects[1][2].
CAS Number
2829282-00-8
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ly367385-hydrochloride.html
Purity
99.47
Solubility
DMSO : 125 mg/mL (ultrasonic) |H2O : 12.5 mg/mL (ultrasonic)
Smiles
OC([C@H](C1=C(C=C(C(O)=O)C=C1)C)N)=O.[H]Cl
Molecular Formula
C10H12ClNO4
Molecular Weight
245.66
Precautions
H302, H315, H319, H335
References & Citations
[1]Clark et al. (+) -2-Methyl-4-carboxyphenylglycine (LY 367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg.Med.Chem.Lett. November 1997, 7 (21) : 2777-2780.|[2]Bruno V, et al. Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+) -2-methyl-4 carboxyphenylglycine (LY367385) : comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors. Neuropharmacology. 1999 Feb;38 (2) :199-207.|[3]Chapman AG, et al. Anticonvulsant actions of LY 367385 ((+) -2-methyl-4-carboxyphenylglycine) and AIDA ((RS) -1-aminoindan-1,5-dicarboxylic acid) . Eur J Pharmacol. 1999 Feb 26;368 (1) :17-24.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
MGluR1

Chemical Information

LY367385 hydrochloride
CAS Number2829282-00-8
PubChem CID122360845
IUPAC Name4-[(S)-amino(carboxy)methyl]-3-methylbenzoic acid;hydrochloride
Molecular FormulaC10H12ClNO4
Molecular Weight245.66
Topological Polar Surface Area101
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count16
Formal Charge0
Complexity266
SMILES
CC1=C(C=CC(=C1)C(=O)O)[C@@H](C(=O)O)N.Cl
InChI
InChI=1S/C10H11NO4.ClH/c1-5-4-6(9(12)13)2-3-7(5)8(11)10(14)15;/h2-4,8H,11H2,1H3,(H,12,13)(H,14,15);1H/t8-;/m0./s1
InChIKey
IGKQWSUZDKTEPR-QRPNPIFTSA-N
Chemical Structure
2D Structure
2D structure of LY367385 hydrochloride
CAS: 2829282-00-8
CID: 122360845
Formula: C10H12ClNO4
MW: 245.66
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight245.66
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass245.0454856
Monoisotopic Mass245.0454856
Topological Polar Surface Area101 Ų
Heavy Atom Count16
Formal Charge0
Complexity266
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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