Products for Research Use Only
RegisterLogin

(±) -LY367385

CAT: 0804-HY-135464Size: 1 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0804-HY-135464Size:1 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
(±) -LY367385 is the racemate of LY367385. LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a[1][2].
CAS Number
198419-90-8
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
MGluR
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/racemic-ly367385.html
Purity
98.0
Solubility
H2O : 5.56 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(O)C(N)C1=CC=C(C(O)=O)C=C1C
Molecular Formula
C10H11NO4
Molecular Weight
209.20
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Clark et al. (+) -2-Methyl-4-carboxyphenylglycine (LY 367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg.Med.Chem.Lett. November 1997, 7 (21) : 2777-2780.|[2]V Bruno, et al. Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+) -2-methyl-4 carboxyphenylglycine (LY367385) : comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors. europharmacology. 1999 Feb;38 (2) :199-207.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Alternative Products

CatalogName
T15818-01LY367385
464005(±)-LY367385
GTR19189483-01(±) -LY367385
MBS5799895(+/-)-LY367385
MBS5803083LY367385 hydrochloride
532163LY367385 HCl

Popular Products