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CDK7-IN-30

CAT: 0804-HY-163856Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163856Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK7-IN-30 (Compound 22) is a CDK7 inhibitor (IC50 = 7.21 nM) that effectively inhibits the phosphorylation of RNA Polymerase II and CDK2. CDK7-IN-30 CDK7-IN-30 can induce cell apoptosis and has anti-cancer activity and can be used in cancer research[1].
CAS Number
3040999-70-7
UNSPSC
12352005
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk7-in-30.html
Smiles
CC(C)S(C(C=CC=C1)=C1NC2=NC(N[C@@H]3CC[C@H](CC3)NC(C)=O)=NC=C2Cl)(=O)=O
Molecular Formula
C21H28ClN5O3S
Molecular Weight
466.00
References & Citations
[1]Zhang H, et al. Design, Synthesis, and Biological Evaluation of 2, 4-Diaminopyrimidine Derivatives as Potent CDK7 Inhibitors[J]. ACS Medicinal Chemistry Letters, 2024.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK1; CDK2; CDK3; CDK4; CDK5; CDK6; CDK7; CDK9

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