CDK7-IN-30

• Description:

  CDK7-IN-30 (Compound 22) is a CDK7 inhibitor (IC50 = 7.21 nM) that effectively inhibits the phosphorylation of RNA Polymerase II and CDK2. CDK7-IN-30 CDK7-IN-30 can induce cell apoptosis and has anti-cancer activity and can be used in cancer research[1].

• UNSPSC:

  12352005

• Target:

  Apoptosis; CDK

• Type:

  Reference compound

• Related Pathways:

  Apoptosis; Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/cdk7-in-30.html

• Smiles:

  CC(C)S(C(C=CC=C1)=C1NC2=NC(N[C@@H]3CC[C@H](CC3)NC(C)=O)=NC=C2Cl)(=O)=O

• Molecular Formula:

  C21H28ClN5O3S

• Molecular Weight:

  466.00

• References & Citations:

  [1]Zhang H, et al. Design, Synthesis, and Biological Evaluation of 2, 4-Diaminopyrimidine Derivatives as Potent CDK7 Inhibitors[J]. ACS Medicinal Chemistry Letters, 2024.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  CDK1; CDK2; CDK3; CDK4; CDK5; CDK6; CDK7; CDK9

• CAS Number:

  [3040999-70-7]