mPGES-1/5-LOX-IN-1

mPGES-1/5-LOX-IN-1

• UNSPSC Description: mPGES-1/5-LOX-IN-1 (compound 3j) is a potent and orally active mPGES-1 and 5-LOX dual inhibitor with IC50 values of 0.92, 1.89 µM, respectively. mPGES-1/5-LOX-IN-1 shows anti-inflammatory impact[1].
• Target Antigen: Lipoxygenase; PGE synthase
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;Metabolic Enzyme/Protease
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/mpges-1-5-lox-in-1.html
• Smiles: O=C(C1=C(C)NC(NC1C2=CC=C(OC)C(OC)=C2)=O)NC3=CC=C(S(=O)(N)=O)C=C3
• Molecular Weight: 446.48
• References & Citations: [1]Al-Wahaibi LH, et al. Design and synthesis of new dihydropyrimidine/sulphonamide hybrids as promising anti-inflammatory agents via dual mPGES-1/5-LOX inhibition. Front Chem. 2024 May 10;12:1387923.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported