5-LOX/sEH-IN-1

• UNSPSC Description:

  5-LOX/sEH-IN-1 (Compound 8o) is a dual 5-LOX/sEH-IN-1 inhibitor with cardioprotective effects, exhibiting IC50 values of 3.05 μM and 2.20 nM respectively, and 5-LOX/sEH-IN-1 can also inhibit the activity of COX-2 (IC50=10.50 μM). 5-LOX/sEH-IN-1 has analgesic and anti-inflammatory effects, while reducing ulcer pathogenicity, and can be used to develop anti-inflammatory agents with fewer gastrointestinal and cardiovascular side effects[1].

• Target Antigen:

  COX; Epoxide Hydrolase; Lipoxygenase

• Type:

  Reference compound

• Related Pathways:

  Immunology/Inflammation;Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cox-2-seh-in-2.html

• Smiles:

  N#CC1=C(N)N2C(NC1C3=CC=C(OC)C=C3)=NN=C2C4=CC=CN=C4

• Molecular Weight:

  345.36

• References & Citations:

  [1]Al-Wahaibi L H, et al. New Diaryl-1, 2, 4-triazolo [3, 4-a] pyrimidine Hybrids as Selective COX-2/sEH Dual Inhibitors with Potent Analgesic/Anti-inflammatory and Cardioprotective Properties[J]. ACS Omega, 2024.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported