SCH 486757

• Description :

  SCH 486757 is an orally effective pain peptide receptor (NOP) agonist. SCH 486757 can be used for the study of cough[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Opioid Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/sch-486757.html

• Solubility :

  10 mM in DMSO

• Smiles :

  ClC1=C(C=CC=C1)C(C(C=CC=C2)=C2Cl)N([C@H]3C4)[C@@H](CC3)C[C@@]4(C5=NC=CC=N5)O

• Molecular Formula :

  C24H23Cl2N3O

• Molecular Weight :

  440.36

• Precautions :

  P261-P280-P302+P352

• References & Citations :

  [1]McLeod RL, et al. Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis (2-Chlorophenyl) Methyl]-3- (2-Pyrimidinyl) -8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models. Eur J Pharmacol. 2010 Mar 25;630 (1-3) :112-20.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [524019-25-8]