SCH 486757

• UNSPSC Description:

  SCH 486757 is an orally effective pain peptide receptor (NOP) agonist. SCH 486757 can be used for the study of cough[1].

• Target Antigen:

  Opioid Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/sch-486757.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=C(C=CC=C1)C(C(C=CC=C2)=C2Cl)N([C@H]3C4)[C@@H](CC3)C[C@@]4(C5=NC=CC=N5)O

• Molecular Weight:

  440.36

• References & Citations:

  [1]McLeod RL, et al. Pharmacological profile of the NOP agonist and cough suppressing agent SCH 486757 (8-[Bis(2-Chlorophenyl)Methyl]-3-(2-Pyrimidinyl)-8-Azabicyclo[3.2.1]Octan-3-Ol) in preclinical models. Eur J Pharmacol. 2010 Mar 25;630(1-3):112-20.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 2

• CAS Number:

  524019-25-8