BCL-XL-IN-3

BCL-XL-IN-3

• CAS Number: 1949840-87-2
• UNSPSC Description: BCL-XL-IN-3 (Compound 11) is an inhibitor for BCL-XL with a Ki EC50 of 77.8 nM and 0.07 nM. BCL-XL-IN-3 can be used as ADC toxin for synthesis of Clezutoclax (HY-137774)[1].
• Target Antigen: Bcl-2 Family
• Type: Reference compound
• Related Pathways: Apoptosis
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/bcl-xl-in-3.html
• Smiles: O[C@H](CO)CCNCCO[C@](C1)(C2)C[C@@](C[C@@]2(C3)C)(C[C@]13C)CN4C(C)=C(C(C=CC(N(CCC5=CC=C6)CC5=C6C(NC7=NC8=CC=CC=C8S7)=O)=N9)=C9C(O)=O)C=N4
• Molecular Weight: 834.04
• References & Citations: [1]Judd AS, et al., BCL-XL-targeting antibody-drug conjugates are active in preclinical models and mitigate on-mechanism toxicity of small-molecule inhibitors. Sci Adv. 2024 Oct 4;10(40):eado7120.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported