ProTx-III

• Description:

  ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK) . ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia[1].

• Product Name Alternative:

  μ-TRTX-Tp1a

• UNSPSC:

  12352209

• Target:

  Sodium Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/protx-iii.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@@H](N)CC(O)=O)N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N1[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]2CSSC[C@H](NC3=O)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)[C@H](CC)C)=O)CC4=CNC=N4)=O)CC(C)C)=O)CCCCN)=O)=O)CCCCN)=O)CC(O)=O)=O)CC(N)=O)=O)CCCNC(N)=N)=O)CCC1)=O)CC(N)=O)=O)CSSC[C@H](NC5=O)C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H]3CC6=CNC7=CC=CC=C67)=O)CC(N)=O)=O)CC8=CNC=N8)=O)CC(N)=O)=O)CO)=O)=O)=O)CCCCN)=O)CC9=CNC%10=CC=CC=C9%10)=O)=O)CC%11=CC=CC=C%11)=O)CCCCN)=O)CC(C)C)=O)CSSC[C@H](NC2=O)C(N[C@H](C(NCC(N[C@H](C(N[C@H]5CCCCN)=O)CC(C)C)=O)=O)CO)=O

• Molecular Formula:

  C162H246N52O43S6

• Molecular Weight:

  3802.40

• References & Citations:

  [1]Cardoso FC, et al. Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens. Mol Pharmacol. 2015 Aug;88 (2) :291-303.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  Nav1.7

• CAS Number:

  [1808297-63-3]