ProTx-III

• Description:

  ProTx-III is a selective and potent inhibitor of voltage-gated sodium channel Nav1.7, with an IC50 of 2.1 nM. ProTx-III is a spider venom peptide isolated from the venom of the Peruvian green velvet tarantella. ProTx-III has a typical inhibitor cystine knot motif (ICK) . ProTx-III is able to reverse the pain response. ProTx-III can be used to study diseases such as chronic pain, epilepsy, and arrhythmia[1].

• Product Name Alternative:

  μ-TRTX-Tp1a

• UNSPSC:

  12352209

• Target:

  Sodium Channel

• Type:

  Peptides

• Related Pathways:

  Membrane Transporter/Ion Channel

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/protx-iii.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C ([C@@H] (N) CC (O) =O) N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (NCC (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N1[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H]2CSSC[C@H] (NC3=O) C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N) =O) [C@H] (CC) C) =O) CC4=CNC=N4) =O) CC (C) C) =O) CCCCN) =O) =O) CCCCN) =O) CC (O) =O) =O) CC (N) =O) =O) CCCNC (N) =N) =O) CCC1) =O) CC (N) =O) =O) CSSC[C@H] (NC5=O) C (NCC (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H] (C (N[C@H]3CC6=CNC7=CC=CC=C67) =O) CC (N) =O) =O) CC8=CNC=N8) =O) CC (N) =O) =O) CO) =O) =O) =O) CCCCN) =O) CC9=CNC%10=CC=CC=C9%10) =O) =O) CC%11=CC=CC=C%11) =O) CCCCN) =O) CC (C) C) =O) CSSC[C@H] (NC2=O) C (N[C@H] (C (NCC (N[C@H] (C (N[C@H]5CCCCN) =O) CC (C) C) =O) =O) CO) =O

• Molecular Formula:

  C162H246N52O43S6

• Molecular Weight:

  3802.40

• References & Citations:

  [1]Cardoso FC, et al. Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens. Mol Pharmacol. 2015 Aug;88 (2) :291-303.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  Nav1.7

• CAS Number:

  1808297-63-3