ProTx-III

CAT: 0466-PTX003-00100Size: 0.1 mgDry Ice: NoHazardous: No
CAT#:0466-PTX003-00100Size:0.1 mg
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Description
ProTx-III (ยต-TRTX-Tp1a; belongs to NaSpTx family 1) has been isolated from the venom of the Peruvian green-velvet tarantula Thrixopelma pruriens at the University of Queensland (Australia) . ProTx-III has been described to be a selective inhibitor of Nav1.7 with an IC50 value around 2 nM. The synthetic version of Tp1a produced by Smartox yields similar results in terms of Nav1.7 inhibition (see Figure 1) . Queensland scientists have described that ProTx-III induces no significant changes in the voltage dependence of activation or steady-state inactivation of Nav1.7. ProTx-III also inhibits Nav1.1, Nav1.2 and Nav1.6 at nanomolar concentrations and does not affects Cav channels and nicotinic acetylcholine receptors. ProTx-III demonstrates analgesic properties in vivo when injected intraplantary in mice prior treatment with OD1, an activator of Nav1.7, which induces spontaneous pain.
Specifications
Selective Nav1.7 blocker
Target
Na channels
Sequence
DCLKFGWKCNPRNDKCCSGLKCGSNHNWCKLHI
Peptide Number
PTX003
Disulfide Bonds
Cys2-Cys17; Cys9-Cys22; Cys16-Cys29
N Terminal Sequence
H
C Terminal Sequence
NH2

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