Cathepsin C-IN-5

CAT:
804-HY-146584-04
Size:
25 mg
  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
Cathepsin C-IN-5 - image 1

Cathepsin C-IN-5

  • UNSPSC Description:

    Cathepsin C-IN-5 (compound SF38) is a potent, selective and orally active Cathepsin C inhibitor with IC50s of 59.9 nM, 4.26 μM, >5 μM, >5 μM, >5 μM for Cat C, Cat L, Cat S, Cat B, Cat K, respectively. Cathepsin C-IN-5 inhibits the Cat C activity in bone marrow and blood. Cathepsin C-IN-5 decreases the activation of NSPs (neutrophil serine proteases). Cathepsin C-IN-5 shows anti-inflammatory activity[1].
  • Target Antigen:

    Cathepsin
  • Type:

    Reference compound
  • Related Pathways:

    Metabolic Enzyme/Protease
  • Applications:

    COVID-19-immunoregulation
  • Field of Research:

    Inflammation/Immunology
  • Assay Protocol:

    https://www.medchemexpress.com/cathepsin-c-in-5.html
  • Solubility:

    DMSO : 20 mg/mL (ultrasonic;warming;heat to 60°C)
  • Smiles:

    CC(NC1=CC=CC(NC2=C(C=NC(NC3=NC=C(C=C3)C4=CSC=C4)=N2)Cl)=C1)=O
  • Molecular Weight:

    436.92
  • References & Citations:

    [1]Chen X, et al. Non-peptidyl non-covalent cathepsin C inhibitoEEr bearing a unique thiophene-substituted pyridine: Design, structure-activity relationship and anti-inflammatory activity in vivo. Eur J Med Chem. 2022 Jun 5;236:114368.
  • Shipping Conditions:

    Room Temperature
  • Clinical Information:

    No Development Reported
  • CAS Number:

    2825567-97-1