Cathepsin C-IN-3

• UNSPSC Description:

  Cathepsin C-IN-3 (compound SF11) is a potent Cathepsin C (Cat C) inhibitor, with an IC50 of 61.79 nM. Cathepsin C-IN-3 also inhibits THP-1 and U937 cell, with IC50 values of 101.5 and 86.5 nM, respectively[1].

• Target Antigen:

  Cathepsin

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cathepsin-c-in-3.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(NC1=CC=C(C=C1)C2=C(N=C(N=C2)NC3=NC=C(C=C3)C4=CSC=C4)NC5=CC(C(F)(F)F)=CC=C5)=O

• Molecular Weight:

  546.57

• References & Citations:

  [1]Chen X, et al. Non-peptidyl non-covalent cathepsin C inhibitoEEr bearing a unique thiophene-substituted pyridine: Design, structure-activity relationship and anti-inflammatory activity in vivo. Eur J Med Chem. 2022 Jun 5;236:114368.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2825567-71-1