Cathepsin C-IN-4

• UNSPSC Description:

  Cathepsin C-IN-4 (compound SF27) is a potent Cathepsin C (Cat C) inhibitor, with an IC50 of 65.6 nM. Cathepsin C-IN-4 also inhibits THP-1 and U937 cell, with IC50 values of 203.4 and 177.6 nM, respectively[1].

• Target Antigen:

  Cathepsin

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/cathepsin-c-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  FC(F)(C1=CC=CC(NC2=C(C=NC(NC3=CC=CC(C4=CSC=C4)=C3)=N2)Cl)=C1)F

• Molecular Weight:

  446.88

• References & Citations:

  [1]Chen X, et al. Non-peptidyl non-covalent cathepsin C inhibitoEEr bearing a unique thiophene-substituted pyridine: Design, structure-activity relationship and anti-inflammatory activity in vivo. Eur J Med Chem. 2022 Jun 5;236:114368.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2825567-86-8