Cathepsin L-IN-5

• UNSPSC Description:

  Cathepsin L-IN-5 (D6-3) is a potent Cathepsin L (CatL) inhibitor with an IC50 of 0.27 nM. Cathepsin L-IN-5 effectively blocks the CatL function and substantially hinders the entry of the SARS-CoV-2 pseudovirus to cells by inhibiting the cleavage of the spike protein. Cathepsin L-IN-5 can be utilized in SARS-CoV-2 research[1].

• Target Antigen:

  Cathepsin

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-anti-virus

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/cathepsin-l-in-5.html

• Smiles:

  O=C(C1=C2C=CC=CC2=CC=C1)N[C@H](C(N[C@@H](CC3=CC=CC=C3)C(CCl)=O)=O)CC4=CC=C(C=C4)F

• Molecular Weight:

  516.99

• References & Citations:

  [1]Deng W, et al. Peptidomimetic Analogues Act as Effective Inhibitors against SARS-CoV-2 by Blocking the Function of Cathepsin L. J Med Chem. 2024 Oct 10;67(19):17124-17143.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported