SR-717

CAT: 0804-HY-131454-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-131454-01Size:5 mg
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Description
SR-717 is a non-nucleotide STING agonist with EC50s of 2.1 μM and 2.2 μM in ISG-THP1 (WT) and ISG-THP1 cGAS KO (cGAS KO) cell lines, respectively. SR-717 is a stable cyclic guanosine monophosphate-adenosine monophosphate (cGAMP) mimetic. Antitumor activity[1].
CAS Number
[2375421-09-1]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
STING
Type
Reference compound
Related Pathways
Immunology/Inflammation
Applications
Cancer-programmed cell death
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/sr-717.html
Concentration
10mM
Purity
99.89
Solubility
DMSO : 10 mg/mL (ultrasonic) |Methanol : 3.33 mg/mL (ultrasonic)
Smiles
O=C(O[Li])C1=CC(F)=C(F)C=C1NC(C2=NN=C(N3C=CN=C3)C=C2)=O
Molecular Formula
C15H8F2LiN5O3
Molecular Weight
351.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Emily N Chin, et al. Antitumor activity of a systemic STING-activating non-nucleotide cGAMP mimetic. Science. 2020 Aug 21;369 (6506) :993-999.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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