PCSK9-IN-10
CAT:
804-HY-152221-04
Size:
10 mg
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PCSK9-IN-10
- CAS Number: 368434-98-4
- UNSPSC Description: PCSK9-IN-10 is a potent and orally active PCSK9 inhibitor with an IC50 value of 6.4 µM. PCSK9-IN-10 increases the expression of LDLR protein and decreases the expression of PCSK9. PCSK9-IN-10 reduces atherosclerosis progression. PCSK9-IN-10 has the potential for the research of hyperlipidemia[1].
- Target Antigen: PCSK9
- Type: Reference compound
- Related Pathways: Metabolic Enzyme/Protease
- Applications: Metabolism-sugar/lipid metabolism
- Field of Research: Metabolic Disease; Cardiovascular Disease
- Assay Protocol: https://www.medchemexpress.com/pcsk9-in-10.html
- Solubility: DMSO : 250 mg/mL (ultrasonic)
- Smiles: O=C(N1C)N(C)C2=C(N(CC3=CC=CC(OC)=C3)C(NCCOC)=N2)C1=O
- Molecular Weight: 373.41
- References & Citations: [1]Qiao MQ, et al. Structure-activity relationship and biological evaluation of xanthine derivatives as PCSK9 inhibitors for the treatment of atherosclerosis. Eur J Med Chem. 2022 Dec 26;247:115047.
- Shipping Conditions: Blue Ice
- Clinical Information: No Development Reported