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PS-166276

CAT: 0804-HY-167877Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-167877Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PS-166276 is a highly potent and less cytotoxic inhibitor of p38. PS166276 has an IC50 of 28 nM at p38 kinase and 170 nM in the THP-1 TNFα assay[1].
CAS Number
348089-57-6
UNSPSC
12352005
Target
P38 MAPK
Type
Reference compound
Related Pathways
MAPK/ERK Pathway
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ps-166276.html
Smiles
CC(C)CN(C)C1=NC(N[C@@H]2CCNC2)=NC(NC3=CC(C(N)=O)=CC=C3C)=N1
Molecular Formula
C20H30N8O
Molecular Weight
398.51
References & Citations
[1]Tsung H Lin, et al. Discovery and characterization of triaminotriazine aniline amides as highly selective p38 kinase inhibitors. J Pharmacol Exp Ther. 2006 Aug;318 (2) :495-502.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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