PS-166276

• Description:

  PS-166276 is a highly potent and less cytotoxic inhibitor of p38. PS166276 has an IC50 of 28 nM at p38 kinase and 170 nM in the THP-1 TNFα assay[1].

• UNSPSC:

  12352005

• Target:

  P38 MAPK

• Type:

  Reference compound

• Related Pathways:

  MAPK/ERK Pathway

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/ps-166276.html

• Smiles:

  CC (C) CN (C) C1=NC (N[C@@H]2CCNC2) =NC (NC3=CC (C (N) =O) =CC=C3C) =N1

• Molecular Formula:

  C20H30N8O

• Molecular Weight:

  398.51

• References & Citations:

  [1]Tsung H Lin, et al. Discovery and characterization of triaminotriazine aniline amides as highly selective p38 kinase inhibitors. J Pharmacol Exp Ther. 2006 Aug;318 (2) :495-502.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  348089-57-6