PS-1145 (Standard)

CAT: 0804-HY-18008RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-18008RSize:1 Each
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Description
PS-1145 (Standard) is the analytical standard of PS-1145. This product is intended for research and analytical applications. PS-1145 is an IκB kinase (IKK) inhibitor with an IC50 of 88 nM.
CAS Number
[431898-65-6]
UNSPSC
12352100
Target
Apoptosis; IKK; Reference Standards
Related Pathways
Apoptosis; NF-κB; Others
Field of Research
Cancer
Smiles
O=C(C1=CC=CN=C1)NC2=CC(Cl)=CC3=C2NC4=C3C=CN=C4
Molecular Formula
C17H11ClN4O
Molecular Weight
322.75
References & Citations
[1]Hideshima T, et al. NF-kappa B as a therapeutic target in multiple myeloma. J Biol Chem. 2002 May 10;277 (19) :16639-47.|[2]Vodanovic-Jankovic S, et al. NF-kappaB as a target for the prevention of graft-versus-host disease: comparative efficacy of bortezomib and PS-1145. Blood. 2006 Jan 15;107 (2) :827-34.|[3]Oh-I S, et al. Central administration of interleukin-4 exacerbates hypothalamic inflammation and weight gain during high-fat feeding. Am J Physiol Endocrinol Metab. 2010 Jul;299 (1) :E47-53.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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