SARS-CoV-2-IN-14

SARS-CoV-2-IN-14

• CAS Number: 22203-98-1
• UNSPSC Description: SARS-CoV-2-IN-14 (compound 6) is a potent inhibitor of SARS-CoV-2 with an IC50 of 0.39 μM. SARS-CoV-2-IN-14 is a niclosamide analogue. SARS-CoV-2-IN-14 contains higher stability in human plasma and liver S9 enzymes assay than niclosamide, which can improve bioavailability and half-life when administered orally[1].
• Target Antigen: SARS-CoV
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: COVID-19-anti-virus
• Field of Research: Infection
• Assay Protocol: https://www.medchemexpress.com/sars-cov-2-in-14.html
• Solubility: DMSO : 250 mg/mL (ultrasonic)
• Smiles: O=C(C1=C(C=CC(Cl)=C1)O)NC2=CC(Cl)=CC=C2
• Molecular Weight: 282.12
• References & Citations: [1]Juang YP, et al. Design, synthesis and biological evaluations of niclosamide analogues against SARS-CoV-2. Eur J Med Chem. 2022 May 5;235:114295.
• Shipping Conditions: Room Temperature
• Clinical Information: No Development Reported