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LC3A rabbit pAb

CAT: 0855-ES20427-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES20427-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:Probably involved in formation of autophagosomal vacuoles (autophagosomes) ., PTM:The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II., similarity:Belongs to the MAP1 LC3 family., subcellular location:LC3-II binds to the autophagic membranes., subunit:3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins., tissue specificity:Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
Description
Function: Probably involved in formation of autophagosomal vacuoles (autophagosomes). PTM: The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II. similarity: Belongs to the MAP1 LC3 family. subcellular location: LC3-II binds to the autophagic membranes. subunit: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. tissue specificity: Most abundant in heart, brain, liver, skeletal muscle and testis but absent in thymus and peripheral blood leukocytes.
UniProt
Q9H492
Swiss Prot
Q9H492
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from human LC3A
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cytoplasmic vesicle, autophagosome membrane ; Lipid-anchor . Endomembrane system ; Lipid-anchor . Cytoplasm, cytoskeleton . LC3-II binds to the autophagic membranes. .
Other Product Names
Microtubule-associated proteins 1A/1B light chain 3A (Autophagy-related protein LC3 A; Autophagy-related ubiquitin-like modifier LC3 A; MAP1 light chain 3-like protein 1; MAP1A/MAP1B light chain 3 A; MAP1A/MAP1B LC3 A; Microtubule-associated protein 1 light chain 3 alpha)
Gene ID (Human)
84557

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