Donitriptan (mesylate)

• Description :

  Donitriptan Mesylate is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively[1].

• Product Name Alternative :

  F-11356 (mesylate)

• UNSPSC :

  12352005

• Target :

  5-HT Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; Neuronal Signaling

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Neurological Disease

• Assay Protocol :

  https://www.medchemexpress.com/donitriptan-mesylate.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CS(=O)(O)=O.NCCC1=CNC2=C1C=C(OCC(N3CCN(C4=CC=C(C#N)C=C4)CC3)=O)C=C2

• Molecular Formula :

  C24H29N5O5S

• Molecular Weight :

  499.58

• References & Citations :

  [1]Muñoz-Islas E, et al. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Br J Pharmacol. 2006 Sep;149 (1) :82-91.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  5-HT1 Receptor

• CAS Number :

  [200615-15-2]