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Donitriptan (hydrochloride)

CAT: 0804-HY-103091Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-103091Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Donitriptan hydrochloride (F-11356) is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively[1].
CAS Number
170911-68-9
Product Name Alternative
F-11356
UNSPSC
12352005
Hazard Statement
H301-H312-H315-H319-H332-H335
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/donitriptan-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
N#CC1=CC=C(N2CCN(C(COC3=CC4=C(NC=C4CCN)C=C3)=O)CC2)C=C1.[H]Cl
Molecular Formula
C23H26ClN5O2
Molecular Weight
439.94
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Muñoz-Islas E, et al. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Br J Pharmacol. 2006 Sep;149 (1) :82-91.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor; mLAG-3

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