Donitriptan

• Description:

  Donitriptan is a potent, high efficacy agonist at 5-HT1B/1D receptors with pKis of 9.4 and 9.3, respectively[1].

• Product Name Alternative:

  F-11356 (free base)

• UNSPSC:

  12352005

• Target:

  5-HT Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/donitriptan.html

• Purity:

  98.06

• Solubility:

  DMSO : 250 mg/mL (ultrasonic)

• Smiles:

  NCCC1=CNC2=C1C=C(OCC(N3CCN(C4=CC=C(C#N)C=C4)CC3)=O)C=C2

• Molecular Formula:

  C23H25N5O2

• Molecular Weight:

  403.48

• References & Citations:

  [1]Muñoz-Islas E, et al. Donitriptan, but not sumatriptan, inhibits capsaicin-induced canine external carotid vasodilatation via 5-HT1B rather than 5-HT1D receptors. Br J Pharmacol. 2006 Sep;149 (1) :82-91.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT1 Receptor; mLAG-3

• CAS Number:

  [170912-52-4]