PROTAC ERα Degrader-5

PROTAC ERα Degrader-5

• CAS Number: 2158322-33-7
• UNSPSC Description: PROTAC ERα Degrader-5 (compound LP2) consists an ADC linker and a PROTAC, whcih can be conjugated to an antibody to form PACs. PROTAC ERα Degrader-5 conjugated to an antibody is a more marked estrogen receptor-alpha (ERα) degrader compared to PROTAC (without Ab)[1].
• Target Antigen: Estrogen Receptor/ERR; PROTAC-Linker Conjugates for PAC
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related;PROTAC;Vitamin D Related/Nuclear Receptor
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/PAC.html
• Purity: 98.96
• Solubility: DMSO : 70 mg/mL (ultrasonic)
• Smiles: CN(C(COCCOCCNC(C1=CC=C(C(N2[C@@H](C)[C@H](NC([C@H](C)NC)=O)C(N(CC3=C(OC)C=CC4=C3C=CC=C4)C5=C2C=C(C#N)C=C5)=O)=O)C=C1)=O)=O)CCOC(C=C6)=CC=C6/C(C7=CC=C(OCC(C=C8)=CC=C8NC([C@H](CCCNC(N)=O)NC([C@H](C(C)C)NC(CCCCCN9C(C=CC9=O)=O)=O)=O)=O)C=C7)=C(C%10=CC=CC=C%10)/CC
• Molecular Weight: 1674.93
• References & Citations: [1]Thomas Pillow, et al. Protac antibody conjugates and methods of use. WO2017201449A1.
• Shipping Conditions: Blue Ice
• Storage Conditions: -20°C (Powder, stored under nitrogen)
• Clinical Information: No Development Reported