Bendamustine HCl

• Background:

  Bendamustine inhibits mitotic checkpoints and induces mitotic catastrophe by inhibiting several mitosis-related genes such as Polo-like kinase 1, Aurora kinase A, and Cyclin B1. In myeloma cell lines, bendamustine induced apoptosis by cleavage of caspase 3, and resulted in G2 cell cycle arrest. In chronic lymphocytic and mantle cell lymphoma cell lines, bendamustine HCl has been shown to activate both the mitochondrial cell death pathway and caspase-dependent apoptosis.

• Description:

  Bendamustine HCl is an alkylating agent associated with DNA damage (IC50 = 50 µM) . It is a cytostatic agent that displays activity in non-Hodgkin's lymphomas.

• Solubility:

  Soluble in DMSO

• Molecular Formula:

  C16H21Cl2N3O2•HCl

• Shipping Conditions:

  Room Temperature (continental US) or Gel Packs

• Storage Conditions:

  Store at or below –20°C. Solid form is stable at least 12 months from date of receipt, when stored as directed. Do not store aqueous solutions for more than one day.

• Calculated Molecular Weight:

  394.7 Da

• CAS Number:

  3543-75-7