Anagrelide HCl

• Background :

  Anagrelide is a FDA-approved drug for the treatment of essential thrombocythemia. It is originally identified as a potential inhibitor of platelet aggregation. Anagrelide selectively affects thrombocytes while shows no significant effect on white blood cells, erythrocytes, or coagulation. Anagrelide is a potent inotropic agent for dogs with remarkable vasodilatory activity. Additionally, anagrelide can reduce renal blood flow. Furthermore, anagrelide has shown to play roles in other chronic myeloproliferative disorders, such as polycythemia vera, chronic myeloid leukemia and agnogenic myeloid metaplasia. Anagrelide has some side effects involving headache, diarrhea, edema, palpitations, and abdominal pain.

• Description :

  Anagrelide is a selective thrombocytopenic agent that inhibits PDE3. It also has been used in the treatment of chronic myeloid leukemia.

• Purity :

  ≥ 98%

• Format :

  Solid

• Solubility :

  Insoluble in EtOH; insoluble in H2O; ≥ 4.9 mg/mL in DMSO. For obtaining a higher solubility, please warm the tube at 37°C and shake it in the ultrasonic bath for a while. Long-term storage in solution is not recommended. Not stable in diluted solutions.

• Molecular Formula :

  C10H8Cl3N3O

• Shipping Conditions :

  Room Temperature (continental US) or Gel Packs

• Storage Conditions :

  At least 6 months at -20°C.

• Calculated Molecular Weight :

  292.55 Da

• CAS Number :

  58579-51-4